Used in pediatrics, veterinary care or even misused as a recreational drug, ketamine could have promising effects on certain forms of severe depression according to a new study.
< p>French researchers from the Institut du Cerveau in Paris have identified one of the mechanisms explaining the effect of ketamine as an antidepressant.
Ketamine, generally used as an anesthetic, has been administered to patients with severe resistant depression. A total of 26 patients with severe resistant depression and 30 healthy control participants participated in the research.
“This treatment led patients to exhibit a greater ability to overcome negative beliefs about themselves themselves and the world when researchers presented them with positive information,” found the study published in JAMA Psychiatry.
About one-third of people with depression do not respond to most prescribed antidepressants , leading to a diagnosis of treatment-resistant depression.
These results open up new therapeutic avenues for the management of antidepressant-resistant mood disorders.
So Whereas conventional antidepressant treatments take time to be effective (on average three weeks), ketamine has a rapid antidepressant effect, just a few hours after administration. The mechanisms associated with this fast-acting antidepressant effect are still unknown.