After Contracting hepatitis b in the body humanized mice showed particular immune and inflammatory responses.
Chinese researchers have created a so-called humanized mice to study the effects of hepatitis B.
In the body functioning of these animals contain human immune cells, reported the online edition of the Chronicle.info with reference to nv.ua.
The creation of an ideal animal model of infection with hepatitis b virus is difficult because the virus has an extremely narrow range of substrates and affects almost exclusively human.
Previous studies show that stem cells of human bone marrow (hBMSCs) in laboratory conditions have the potential to split into hepatocyte-like cells and support the basic functions of liver cells outside a living organism after transplantation into the liver of the mouse. Hepatocytes constitute from 70 to 85 percent of the mass of the liver.
The scientific staff of Xiamen and Zhejiang universities hBMSCs transplanted into mice. Functional human hepatocytes and multiple immune cells showed a high ability to differentiate.
After Contracting hepatitis b in the body humanized mice showed particular immune and inflammatory responses, and symptoms of progressive chronic liver cirrhosis and hepatitis.
According to the opinion of scientists, infection with hepatitis causes a new model of humanized mice with liver cirrhosis. Thus, the results of the study provide material for a better understanding of the immune pathophysiology of the virus and the testing of antiviral therapies in the future.