The race for cures: expected results by the end of the month for colchicine

La course aux remèdes: des résultats attendus d’ici la fin du mois pour la colchicine

The positive results of a study on a steroid anti-inflammatory against the COVID-19 gives hope to researchers in montreal at the head of a vast research on the colchicine. The results of this project are expected by the end of the month.

“It is a little bit between two chairs “, admits the director of the draft study on colchicine, Dr. Jean-Claude Tardif.

With his team of researchers from the Montreal heart Institute (MHI) and their partners, they have practically found all of the guinea pigs.

But the doctor is still awaiting results from the council of independent security, which oversees the study.

“This is not just the number of participants. It is that there are a series of interim analyses that must be made by the committee of safety of the study. It is not that I hide you something, I don’t know the results moi non plus “, argues the expert.

Stop the storm inflammatory

Colchicine is an anti-inflammatory already existing on the market, which, according to the thesis of the team, would help to neutralize the devastating effects of the COVID-19 in vulnerable individuals.

Inexpensive, this molecule would stop the storm-inflammatory which leads to hospitalization and sometimes causes death.

“We should have the first results towards the end of June. And there, we’ll see whether they are interim or final. But, it is sure that you will say something before the end of the month, ” he promises.

At the head of the extensive study on colchicine, Dr. Tardif is, however, very confident, especially since the unveiling of a study on dexamethasone, a medication in the family of steroids.

The dexamethasone has been reduced by one third the mortality in patients with the most severely affected by the COVID-19.

This medicine is also used in many indications for its anti-inflammatory effect very powerful.

“We are optimistic “

The positive results of this medicine have inflated hope Dr. Tardif and his team. “We are optimistic,” he says.

The positive effects of this drug is limited, however, to persons who are intubées and in a critical state.

For colchicine, Dr. Tardif noted that it would be effective to prevent hospitalisations and reduce these complications.

“Obviously for us, this is very good news,” says the researcher.

The study in brief

 

  • Colchicine comes from a flower of autumn, which is called colchicine.
  • It has an anti-inflammatory effect.
  • It is usually prescribed for the treatment of gout.
  • Cost : $ 1 per day for the treatment.
  • 6000 guinea pigs for the study anywhere in the world.
  • A grant of Québec of$ 5.4 Million for the study.
  • A grant of$ 3 Million from the Bill and Melinda Gates foundation.
  • Partnership with the Institute of national health, u.s. National Institutes of Health).
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