Towards a cure for deafness?

Towards a cure for deafness?


The hearing loss that affects a significant proportion of the elderly is an irreversible phenomenon, which considerably reduces the quality of life. A recent biochemical discovery suggests that regenerating the cells responsible for capturing sound waves may offer a novel therapeutic approach to address this problem.

The seat of hearing is located at the level of the cochlea, a snail-shaped structure that is located in the inner ear. The cochlea is lined with hair cells that have the particularity of transforming sound waves into electrical signals and sending them to the brain where they are then interpreted. 

This transformation calls for the collaboration of two distinct types of hair cells, located in two distinct regions of the cochlea: the external cells, in the shape of a cylinder, which deform in response to the pressure exerted by the sound waves and convert these waves into an electrical signal, and the internal, pear-shaped cells that integrate this signal and transfer it to the brain via nerve fibers.  

Hearing loss

The outer hair cells that pick up sounds from the environment are formed during fetal development and no longer regenerate during our lifetime. As a result, when these cells are damaged during aging, hearing acuity is irreversibly reduced. 

This is unfortunately a very common phenomenon: in America, approximately 10 adults aged 55-64 have hearing loss, a proportion that reaches 25 % among those aged 65-74 and over 50 % among those 75 and over.  

Building hearing cells

Currently, it is possible to produce hair cells artificially, but these cells are not able to restore hearing, because they do not differentiate into outer or inner cells. 

Results recently published in the prestigious journal Nature suggest, however, that this differentiation is possible in the short and medium term. 

Researchers have in fact shown that a single gene (called Tbx2) alone is capable of determining the fate of a hair cell: if the gene is active, the hair cell becomes internal, while if it is inactive, the cell becomes external.(1)

In other words, it would be possible to produce one or the other type of hearing cells depending on the degree of activation of the Tbx2 gene, which could eventually make it possible to create in the laboratory the cells required to restore hearing loss caused by the disappearance of these cells.

Obviously, there is still a long way to go, but these data illustrate how important scientific research is to determine the molecular biochemical mechanisms responsible for a physiological process and the possible solutions that can be envisaged to correct a pathology affecting these systems.

Prevention of hearing loss

In the meantime, it is important to note that factors other than age can accelerate the deterioration of auditory functions, in particular physical (repetitively high sound levels), chemical (such as certain chemotherapy drugs) or metabolic (diabetes and obesity, in particular). 

This link between overweight and diabetes and auditory functions may seem surprising at first glance, but it should be remembered that type 2 diabetes is associated with a host of vascular and neurological complications, which can affect hearing when vessels and nerves affected by the disease are located in the inner ear.  

This would explain why studies have repeatedly reported a correlation between the presence of diabetes (or blood glucose levels above normal) and hearing loss.(2)  

Similar correlations have been reported for obesity, possibly because being overweight is a factor risk of diabetes. 

This is another example of the many unfortunate consequences that flow from being overweight and the diseases associated with it.

  • (1) García-Añoveros et al. Tbx2 is a master regulator of inner versus outer hair cell differentiation. Nature 2022; 605: 298–303.
  • (2) Rim HS et al. Association of metabolic syndrome with sensorineural hearing loss. J. Clin. Med. 2021; 10:4866.